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目的探讨参芎葡萄糖注射液和血液滤过联合治疗高血脂症性胰腺炎的临床效果。方法将高血脂症性胰腺炎患者61例随机分为研究组(31例)和对照组(30例),对照组实施常规内科治疗和血液滤过治疗,研究组在此基础上加用参芎葡萄糖注射液治疗。比较2组治疗前后三酰甘油(TG)、炎症因子、血浆黏度、全血黏度、APACHEⅡ评分,统计其腹痛消失时间、住院时间、器官衰竭发生率、病死率,并评定临床疗效。结果研究组治疗后的血清TG含量、炎症因子(IL-6、IL-8)、血浆黏度、全血黏度(高切、低切)水平、APACHEⅡ评分均较治疗前明显降低(P均<0.05),且明显低于对照组(P均<0.05);研究组总有效率明显高于对照组(P<0.05);研究组患者腹痛消失时间、住院时间均短于对照组(P均<0.05),器官衰竭发生率低于对照组(P<0.05);但2组病死率对比无明显差异(P>0.05)。结论参芎葡萄糖注射液和血液滤过联合治疗高血脂症性胰腺炎可迅速降低血脂水平,清除炎性介质,缩短治疗时间,改善预后,效果显著,值得推广。
Objective To investigate the clinical effect of Shenxiong glucose injection and hemofiltration in the treatment of hyperlipidemic pancreatitis. Methods Sixty-one patients with hyperlipidemic pancreatitis were randomly divided into study group (n = 31) and control group (n = 30). The control group received routine medical therapy and hemofiltration. In addition, Glucose injection treatment. The triglyceride (TG), inflammatory factors, plasma viscosity, whole blood viscosity, APACHEⅡscore were compared between the two groups before and after treatment. The disappearance time of abdominal pain, hospitalization time, the incidence of organ failure and mortality were calculated and the clinical efficacy was evaluated. Results The levels of serum TG, IL-6 and IL-8, the viscosity of whole blood (high-cut, low-cut) and APACHEⅡ in study group were significantly lower than those before treatment ), And significantly lower than that of the control group (all P <0.05). The total effective rate in the study group was significantly higher than that in the control group (P <0.05). The disappearance time and hospital stay of the study group were shorter than those in the control group ), The incidence of organ failure was lower than that of the control group (P <0.05), but no significant difference was found between the two groups (P> 0.05). Conclusion Shenxiong glucose injection and hemofiltration combined treatment of hyperlipidemic pancreatitis can rapidly reduce blood lipid levels, clear inflammatory mediators, shorten the treatment time and improve prognosis, the effect is significant and worth promoting.