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血栓性血小板减少性紫癜(TTP)是一种以微血管病性溶血性贫血、血小板减少、神经系统异常、发热和肾功能受损为主要特征的综合征。近20年内,随着皮质类固醇激素、切脾、血液透析和抗血小板药物的使用,对TTP的治疗已取得一些进展,尤其是全血交换输血法(WBET)的使用,所获疗效更佳,据此所进行的一些血浆输入(PI)和新鲜冰冻血浆交换(PE)的治疗试验也取得很大成功。
Thrombotic thrombocytopenic purpura (TTP) is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurological abnormalities, fever and impaired renal function. In the recent 20 years, with the use of corticosteroids, splenectomy, hemodialysis and anti-platelet drugs, some progress has been made in the treatment of TTP. In particular, the use of WBET has achieved better results, Some of the treatment trials for plasma input (PI) and fresh frozen plasma exchange (PE) have also been very successful.