论文部分内容阅读
缺血缺氧引起的肾损伤不但可以发生在组织灌流不足的当时,更重要的是发生在肾组织再灌注之后,这一现象称之为“肾组织再灌注损伤”。低血压和低血容量所致的急性肾功能良竭(ARF)较心、脑和肝功能衰竭更为常见和严重。新近的研究证实,一些因素在肾缺血再灌注细胞损伤中起重要作用,综述如下: 一、嘌呤池耗竭: 细胞能量代谢及DNA、RNA和蛋白质合成主要由高能磷酸键供能。一旦ATP的合成
Ischemia and hypoxia-induced kidney damage can occur not only at the time of tissue hypoperfusion, but more importantly after renal tissue reperfusion, a phenomenon known as “renal tissue reperfusion injury.” Acute renal insufficiency (ARF) due to hypotension and hypovolemia is more common and severe than heart, brain and liver failure. Recent studies have confirmed that a number of factors play an important role in renal ischemia-reperfusion cell injury and are summarized as follows: 1. Purine cell depletion: cellular energy metabolism and DNA, RNA and protein synthesis are mainly powered by high-energy phosphate bonds. Once ATP is synthesized