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目的：探讨抑制一氧化氮（ ｎｉｔｒｉｃ ｏｘｉｄｅ ， Ｎ Ｏ） 合成对孕鼠血压、蛋白尿、胎鼠及胎盘的影响，以探讨 Ｎ Ｏ 在妊高征发病中的作用。方法： 皮下注射一氧化氮合成酶抑制剂、一氧化氮合成前体物质。妊娠１４ 天的大鼠分为用药组、对照组、治疗组，观察其血压、尿蛋白、胎鼠及胎盘的变化。结果发现用药组血压及尿蛋白含量在用药第二天开始升高并维持至分娩，与治疗组及对照组相比差别显著（ Ｐ ＜ ０ ．０１） ；用药组的胎鼠与胎盘重量明显小于对照组及治疗组（ Ｐ＜ ０ ．０１） ； 这说明妊娠晚期皮下注射一氧化氮合成酶抑制剂抑制一氧化氮合成， 可使孕鼠产生类似妊高征的特征，一氧化氮合成前体物质可对抗此作用。
Objective: To investigate the effect of nitric oxide (NO) synthesis on the blood pressure, proteinuria, fetal rat and placenta in pregnant rats to explore the role of NO in the pathogenesis of PIH. METHODS: A nitric oxide synthase inhibitor was injected subcutaneously to synthesize precursors of nitric oxide. The 14-day pregnant rats were divided into treatment group, control group and treatment group. The changes of blood pressure, urinary protein, fetal rat and placenta were observed. The results showed that the blood pressure and urinary protein content in the medication group began to increase and maintained until the second day of treatment, which was significantly different from the treatment group and the control group (P <0.01). The weight of the fetus and placenta of the medication group was significantly less than Control group and treatment group (P <0.01); This shows that the subcutaneous injection of nitric oxide synthase inhibitors in the third trimester of pregnancy inhibits the synthesis of nitric oxide, pregnancy-induced pregnancy-induced hypertension can be similar characteristics of nitric oxide precursor Matter can combat this effect.