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目的检测急性心肌梗死(AMI)患者血清T辅助细胞17(T help cell 17,Th17)相关细胞因子IL-17、IL-23和IL-27水平,观察它们在AMI中的变化,探讨其在AMI中的意义。方法用ELISA检测AMI患者及健康对照组血清IL-17、IL-23和IL-27水平。结果 AMI患者血清IL-17、IL-23和IL-27水平明显高于健康对照组(P<0.01)。结论 AMI患者Th17相关细胞因子水平升高,提示它们在AMI中可能起重要作用。
Objective To detect the levels of IL-17, IL-23 and IL-27 in serum of T helper cell 17 (Th17) in patients with acute myocardial infarction (AMI) and to observe their changes in AMI. In the meaning. Methods Serum levels of IL-17, IL-23 and IL-27 were measured by ELISA in patients with AMI and healthy controls. Results The levels of serum IL-17, IL-23 and IL-27 in AMI patients were significantly higher than those in healthy controls (P <0.01). Conclusion Th17-associated cytokines levels in AMI patients suggest that they may play an important role in AMI.