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作者对在恶性淋巴肉芽肿进行化疗中发生带状疱疹者,采用Ara—A 治疗,收到良好的效果。Ara—A(阿糖腺苷),是1960年由Lee 等人作为抗肿瘤药而合成的,其结构与deoxyadenosine 相似。作者认为对疱疹病毒、巨细胞病毒、牛痘病毒、水痘带状疱疹病毒等病毒的DNA 发挥抗病毒作用,其机制是能阻断病毒DNA 所依赖的DNA 聚合酶而使DNA 合成受抑制。在原发病的基础上,特别是在恶性肿瘤或自身免疫疾病基础上并发的带状疱疹,因容易扩散,多数在疱疹消退后遗留神经痛。因此,认为必须早期施行有效的治疗。有人报告Ara—A 治疗单纯疱疹有效,用Ara—A 治疗后,不仅早期就能控制疱疹,并且疼痛等神经症状也会迅速消失。它同抗生素问世后细菌
The authors of shingles in the chemotherapy of malignant lymphogranuloma who, using Ara-A treatment, received good results. Ara-A (arabinoside), synthesized in 1960 by Lee et al as an antineoplastic agent, has a similar structure to deoxyadenosine. The authors believe that the anti-virus effect on the DNA of herpes virus, cytomegalovirus, vaccinia virus, varicella-zoster virus and other viruses can be blocked by inhibiting the DNA polymerase on which the DNA depends. On the basis of the primary disease, especially complicated with malignant tumors or autoimmune diseases, shingles often spread neuralgia after herpes subsides due to easy spread. Therefore, we believe that effective treatment must be given early. Ara-A was reported to be effective in the treatment of herpes simplex, and after Ara-A treatment, not only herpes can be controlled early but also the neurological symptoms such as pain disappear quickly. It comes with bacteria after the advent of antibiotics