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目的探讨18F-FDG SPECT/CT检查结合CA15-3检测在乳腺癌术后复发病例的早期诊断价值。方法对62例乳腺癌术后病例同时进行18F-FDG SPECT/CT检查和CA15-3检测,怀疑复发病例进行CT增强扫描和临床随访,以进一步确诊。结果 62例患者中,18F-FDG SPECT/CT检查发现核素异常浓聚19例,经CT增强扫描和临床资料证实为转移灶12例,阳性率和假阳性率分别为19.4%,11.3%,特异性为86.0%。本组病例CA15-3升高8例,证实为转移灶病例中CA15-3升高6例,阳性率和假阳性率分别为9.8%,3.2%,特异性96.4%。结论 18F-FDG SPECT/CT检查和CA15-3检测是乳腺癌术后复发的可靠检查方法。统计分析表明,18F-FDG SPECT/CT检查异常显著高于CA15-3升高,提示18F-FDG SPECT/CT检查是乳腺癌术后复发的较好方法,18F-FDG SPECT/CT检查结合CA15-3检测可以提高乳腺癌术后转移的诊断率和准确性,在乳腺癌术后复查时联合应用具有重要意义。
Objective To investigate the early diagnostic value of 18F-FDG SPECT / CT combined with CA15-3 in the diagnosis of postoperative recurrence of breast cancer. Methods 62 cases of postoperative breast cancer patients with simultaneous 18F-FDG SPECT / CT and CA15-3 detection, suspected cases of recurrent CT enhanced scan and clinical follow-up for further diagnosis. Results Of the 62 patients, 19 cases of abnormal nuclear accumulation were found by 18F-FDG SPECT / CT examination. Twelve cases were confirmed by CT enhanced scan and clinical data. The positive rate and false positive rate were 19.4%, 11.3% The specificity was 86.0%. This group of patients with elevated CA15-3 in 8 cases, confirmed cases of metastatic CA15-3 increased in 6 cases, the positive rate and false positive rates were 9.8%, 3.2%, specificity 96.4%. Conclusion 18F-FDG SPECT / CT examination and CA15-3 detection is a reliable method for postoperative recurrence of breast cancer. Statistical analysis showed that 18F-FDG SPECT / CT abnormalities were significantly higher than CA15-3, suggesting that 18F-FDG SPECT / CT examination is a good method for postoperative recurrence of breast cancer. 18F-FDG SPECT / CT combined with CA15- 3 detection can improve the diagnosis of breast cancer postoperative metastasis and accuracy in the review of breast cancer combined application of great significance.