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近来发现糖皮质激素在体内外均可诱导胸腺细胞凋亡,这就使T细胞在胸腺中成熟过程的细胞凋亡的调节机理变得复杂。为了发现其它因素对T细胞在胸腺成熟过程的影响及探讨其可能机理,本实验研究了组织胺与地塞米松诱导胸腺细胞凋亡。取Spague-Dawley大鼠胸腺细胞
Recently, glucocorticoids have been found to induce thymocyte apoptosis both in vitro and in vivo, complicating the regulatory mechanism of T cell apoptosis during thymus maturation. In order to find out the effect of other factors on the thymus maturation of T cells and explore its possible mechanism, histamine and dexamethasone induced thymocyte apoptosis in this experiment. Spleen-Dawley rat thymocytes were harvested