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充血性心力衰竭(CHF)是十分常见的临床综合征.其病理生理特征是神经激素系统的广泛激活。近年来发现CHF时多种活性肽和第二信使系统亦有明显的变化。本文就这一问题,结合我们自己的研究结果作一综述。 1 交感神经兴奋 这是CHF时神经激素激活最主要的表现。通常表现为血浆去甲肾上腺素(NE)水平增高。其原因包括(1)肾上腺髓质儿茶酚胺释放增加;(2)中枢神经系统交感神经传出神经活性增加;(3)外周神经末梢释放NE增加和/或神经递质在神经末梢的重吸收减少或代谢异常。与此同时,心衰患者有心肺压力感
Congestive heart failure (CHF) is a very common clinical syndrome whose pathophysiological features are a widespread activation of the neurohormonal system. In recent years found when CHF multiple active peptides and second messenger system also have significant changes. This article reviews this issue, combined with our own findings. 1 Sympathetic Excitement This is the most important manifestation of neurohormonal activation in CHF. Often manifested as plasma norepinephrine (NE) levels increased. The causes include (1) increased adrenal medullary catecholamine release; (2) increased sympathetic nerve efferent activity in the central nervous system; (3) increased NE release and / or decreased reuptake of neurotransmitters at nerve endings or Metabolic abnormalities. At the same time, heart failure patients have heart and lung pressure