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二代抗精神病药物(the second-generation antipsychotic drugs,SGAs)的长期使用易导致患者体重增加、肥胖及其他代谢性疾病,进而引发心脑血管并发症、增加早逝风险。二代抗精神病药物介导的脂代谢紊乱是代谢综合征发展的关键环节。笔者就近年来的文献报道和研究结果,以肝脏、白色脂肪等外周组织中SREBPs/AMPKα/PPAR通路调控及胰岛素抵抗为切入点,综述了二代抗精神病药物介导脂代谢紊乱的相关机制。
The long-term use of the second-generation antipsychotic drugs (SGAs) can easily lead to weight gain, obesity and other metabolic diseases in patients, triggering cardiovascular and cerebrovascular complications and increasing the risk of premature death. Second generation antipsychotic-mediated dyslipidemia is a key link in the development of the metabolic syndrome. The author reported in recent years and the results of the study, liver, white fat and other peripheral tissues SREBPs / AMPKα / PPAR pathway regulation and insulin resistance as the starting point, reviewed the second generation of antipsychotics lipid metabolism disorders related mechanisms.