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背景：长期使用非甾体类抗炎药（NSAIDs）的患者结肠癌发病率明显下降，NSAIDs能抑制环氧合酶（COX），COX－2在结肠癌的发生过程中起有作用。目的：调查COX－2在结肠病变中的表达。方法：用免疫组化方法检测正常和病变结肠组织中COX－2和COX－1蛋白的表达。结果：COX－2蛋白在正常结肠组织中呈低强度表达，在炎症性肠病（IBD）、结肠腺瘤和结肠癌组织中表达强度明显增高。COX－1蛋白在正常结肠粘膜、IBD、结肠腺瘤和结肠癌组织的上皮细胞和间质细胞中均呈低强度表达。结论：COX－2在结肠肿瘤和IBD的发生中可能起有某种作用。
BACKGROUND: The incidence of colon cancer in patients with long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has decreased significantly. NSAIDs can inhibit cyclooxygenase (COX) and COX-2 plays a role in the development of colon cancer. Objective: To investigate the expression of COX-2 in colon lesions. METHODS: The expression of COX-2 and COX-1 protein in normal and diseased colon tissues was detected by immunohistochemistry. RESULTS: COX-2 protein was expressed in low intensity in normal colon tissues, and its expression intensity was significantly increased in inflammatory bowel disease (IBD), colon adenoma, and colon cancer tissues. COX-1 protein expressed low intensity in epithelial cells and stromal cells of normal colon mucosa, IBD, colon adenoma and colon cancer tissues. Conclusion: COX-2 may play a role in the development of colon cancer and IBD.