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本文报告将45只大鼠置入低压舱(模拟海拔5 000 m高度)20～90天及缺氧90天后放回空气中恢复40～120天的生理及病理变化:缺氧鼠的肺动脉平均压及右心室内压最大上升速率明显高于平原对照组(P<0.001),肺动脉中层肥厚、面积增加,心肺超微病变在缺氧90天最明显,两心室病损以右室为重。在缺氧90天恢复120天的肺、心功能及病理变化均几乎恢复到正常状态。
In this paper, 45 rats were placed in the low-pressure cabin (simulated elevation of 5 000 m height) 20 to 90 days and 90 days after hypoxia returned to the air to recover 40 to 120 days of physiological and pathological changes: hypoxic rat pulmonary artery mean pressure And the maximum rate of right ventricular pressure rise was significantly higher than that of the plain control group (P <0.001). The middle pulmonary hypertrophy and area were increased. The cardiopulmonary superficial lesions were the most obvious at 90 days of hypoxia and the right ventricle was heavier in the two ventricular lesions. During the 120-day lung recovery 90 days after hypoxia, cardiac function and pathological changes almost returned to normal.