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60只白兔分为6组,切除L5全椎板后造成12MM*5MM的硬脊膜裸露区,A组不用任何物质充填,B、C、D、E、F组分别充填0.5％,1.0％,1.5％,2.0％和2.5％的透明质酸钠,术后2,4,8周取材行大体、光镜观察和计算机图像分析、结果:A、B、C组硬膜外形成致密粘连,D和E组粘连较轻,F组无明显粘连,透明质酸钠浓度与硬膜周围组织中成纤维细胞讨数、硬脊膜发生粘连长度的百分比间存在显著负相关(P＜0.01),提示透明质酸钠浓度大于1.5％时才有防椎管内粘连的作用.“,”Objective: To study the effect of hyaluronic sodium in different concentration for preventing intraspinal adhesion. Methods: 60white rabbits were divided into 6 groups randomly, 12*5mm naked area of dura mater spinalis was made by resecting all L5vertebral lamina. The group A wasn't filled by anything, whereas the group B, C, D, E and F was filled with 0.5%, 1.0%, 1.5%, 2.0%and 2.5% hyaluronic sodium respectively. The relative tissues were taken for general, optical microscopy and computer-assistedimage analysis on the 2nd, 4th and 8th week after the operation respectively. Results: Extradural compact adhesion formed in thegroup A, B and C, lesser intraspinal adhesion formed in the group D and E, and no obvious adhesion occurred in the group F.There was a significant negative correlation between the concentration of hyaluronic sodium, fibroblast counting in the peripheraltissue of scleromeninx and the adhesion length of dura mater spinalis (P<0.01). Conclusions: The results suggest that hyaluronicsodium will have the preventative effect for intraspinal adhesion only while its concentration is more than 1.5%.