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目的研究常用降压药物不同时间服药对高血压患者凌晨血压的影响。方法 125例高血压患者随机分成2组,A组患者早晨给予络活喜片,B组则晚上给予络活喜片,2组患者均进行24小时动态血压观察,对二者治疗前后的血压及凌晨血压变化、2组间凌晨血压、服药后血压T/P值进行统计分析。结果 2组患者总的降压疗效及24小时血压平均值的T/P比较均无显著性差异(P>0.05),但晚上服药组对控制凌晨高血压的疗效与早晨服药组比较有明显差异性(P<0.05)。结论晚上服药对控制凌晨高血压优于早晨服药。
Objective To study the effect of commonly used antihypertensive drugs on blood pressure in patients with essential hypertension at different times. Methods A total of 125 hypertensive patients were randomly divided into 2 groups: group A received Fuoxin tablets in the morning, group B received Luohuoxin tablets in the evening, both groups were observed 24 hours ambulatory blood pressure, the two before and after treatment of blood pressure and Changes in blood pressure in the early morning, blood pressure in the early morning of two groups, blood pressure T / P value after statistical analysis. Results There was no significant difference in total antihypertensive efficacy and T / P in 24 hours mean blood pressure between the two groups (P> 0.05), but there was a significant difference between the morning medication group and the morning medication group (P <0.05). Conclusions Evening medication is better than morning medication in controlling early morning hypertension.