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目的探讨低分子肝素钙在慢性阻塞性肺疾病急性加重期(AECOPD)中的应用。方法83例慢性阻塞性肺疾病急性加重期的患者随机分为治疗组与对照组。两组患者均予常规治疗,治疗组患者加用低分子肝素钙5000U,皮下注射,每12 h 1次,连续10 d。观察治疗前,及治疗后第1、5、10 d血气分析。结果与对照组相比,治疗组机械通气治疗例数明显减少,住院时间减少,第5、10天动脉血气指标较对照组患者明显改善。结论慢性阻塞性肺疾病急性发作期加用低分子肝素钙可明显提高临床疗效,可以推广使用。
Objective To investigate the application of low molecular weight heparin calcium in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Eighty-three patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into treatment group and control group. Both groups were given routine treatment. The patients in the treatment group were given low molecular weight heparin 5000U subcutaneously once every 12 hours for 10 days. Blood gas analysis was observed before treatment, and on the 1st, 5th, and 10th day after treatment. Results Compared with the control group, the number of mechanical ventilation in the treatment group decreased significantly, the hospitalization time decreased, and the arterial blood gas index on the 5th and 10th was significantly improved compared with the control group. Conclusions The addition of low molecular weight heparin to acute exacerbation of chronic obstructive pulmonary disease can significantly improve the clinical efficacy and can be widely used.