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(1)合成了若干新种类的二苯并五員、六員及七員碘雜环化合物(Ⅲ)→(Ⅻ)。化合物(皿)及(Ⅺ)系以內盐形式存在。这些碘雜环化合物的各种盐类的溶解度性貭与錪盐相似。 (2)化合物(Ⅵ)在碱性介貭中有呈色反应(深兰色)。化合物(Ⅷ)与吡啶共热呈淡兰色。归納实驗結果,碘雜环化合物呈色反应的結构条件为;C_3及C_6位置上有一个至两个硝基,-Ⅰ-对位(即R_3)为-CH-或-CH_2-。 (3)內盐(Ⅷ)的原料——4-硝基-4′-磺酸鉀二苯甲烷是一种新的化合物。 (4)硫氰酸盐(Ⅰ)及(Ⅵ)的吡啶溶液作了吸收光譜:(Ⅰ),λ_(max).730mμ(log ε4.20);半小时后,λ_(max).730mμ(log ε3.30),λ_(max).630mμ(log ε3.79),17.5小时后两峯均消失。(Ⅵ)λ_(max).623mμ(log ε 4.21),18小时后不变。 (5)碘化物(Ⅲ)、(Ⅴ)、(Ⅹ)的热解产物可能为:2,2′-二碘代-4,4-二硝基联苯(Ⅷ)、2,2′-二碘代4,4-二氰基二苯甲烷(ⅩⅣ)、2,2′-二碘代-4,4′-二硝基二苯醚(ⅩⅤ)。 (6)硫酸氫盐(Ⅰ)、氯化物(Ⅴ)、氯化物(Ⅸ)、硫酸氫盐(Ⅹ)对枯草桿菌有抑制生长的作用。 (7)甲酸盐(Ⅱ)进行动物(免)試驗,有显著的降血压作用。 (8)在相同的条件下,4,4′-二硝基二苯硫醚与硫酸正碘酰的反应产物为4,4′-二硝基二苯硫砜,得不到相应含硫碘的雜环化合物。
(1) Several new kinds of dibenzo five-membered, six-membered and seven-membered iodinated heterocyclic compounds (Ⅲ) → (Ⅻ) were synthesized. Compounds (I) and (XI) are in the form of internal salts. The solubility of various salts of these iodinated heterocyclic compounds is similar to that of phosphonium. (2) Compound (VI) has a color reaction in basic medium (dark blue). Compound (VIII) is pyridine blue with a light blue color. According to the experimental results, the structural conditions for the color reaction of iodinated heterocyclic compounds are as follows: one to two nitro groups at the C_3 and C_6 positions, and the -Ⅰ-para (that is, R_3) is -CH- or -CH_2-. (3) The starting salt of internal salt (Ⅷ) - Potassium 4-nitro-4’-sulfonate Diphenylmethane is a new compound. (4) Absorption spectra of the thiocyanate (Ⅰ) and (Ⅵ) pyridine solutions were obtained: (Ⅰ), λ max. 730 mμ (log ε 4.20); after half an hour λ max (max) log ε3.30), λ max (max) .630 mμ (log ε 3.79). Both peaks disappeared after 17.5 hours. (Ⅵ) λ max (max) .623 mμ (log ε 4.21), unchanged after 18 hours. (5) The pyrolysis products of iodides (Ⅲ), (V) and (X) may be 2,2’-diiodo-4,4-dinitrobiphenyl (Ⅷ) Diiodo-4,4-dicyanodiphenylmethane (XIV), 2,2’-diiodo-4,4’-dinitrobenzene (XV). (6) Hydrogen sulfate (Ⅰ), chloride (Ⅴ), chloride (Ⅸ), bisulfate (Ⅹ) inhibit the growth of Bacillus subtilis. (7) formate (II) animal (exempt) test, a significant hypotensive effect. (8) Under the same conditions, the reaction product of 4,4’-dinitrodiphenyl sulfide and n-iodosulfuric acid was 4,4’-dinitrodiphenylsulfone, and no corresponding sulfurous iodine Of heterocyclic compounds.