Oncogenic Role of Skp2 and p27^Kip1 in Intraductal Proliferative Lesions of the Breast

• 作 者: Yan Lv Yun Niu Xiu-min Ding Xu
• 机 构: DepartmentofAcupunctureandMoxibustion,BreastCancerResearchandPathologyLaboratory
• 出 处: 中国医学科学杂志：英文版
• 发表日期: 2012年3期
• 关键词: SKP2 致癌作用 P27 增生性 乳腺癌 病变 管内 石蜡包埋组织 breast cancer intraductal proliferative lesio
• 基金项目: Supported by the National Natural Science Foundation of China（30471967）, research funding of Tianjin Cancer Institute＆Hospitalof Tianjin Medical UniversityACKNOWLEDGMENT The authors gratefully thank V

Objective To investigate whether the connection of p27 Kip1 to S-phase kinase-associated protein 2 (Skp2) plays an oncogenic role in intraductal proliferative lesions of the breast. Methods Here we investigated the mechanism involved in association of Skp