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目前研究认为 ,大部分肿瘤细胞表达端粒酶活性 ,而正常细胞大都没有端粒酶活性表达 ,永生化细胞和恶性肿瘤细胞通过激活端粒酶来维持端粒长度并阻止细胞死亡 ,端粒酶的激活是恶性肿瘤增殖失控的重要原因。端粒酶是一个核糖核蛋白复合体 ,由45 0 bp的 RNA和至少两个蛋白亚单位组
Current studies suggest that most tumor cells express telomerase activity, whereas most normal cells do not express telomerase activity. Immortalized cells and malignant tumor cells maintain telomere length and prevent cell death by activating telomerase. Telomerase The activation of malignant tumors is an important cause of uncontrolled proliferation. Telomerase is a ribonucleoprotein complex consisting of 0.45 bp of RNA and at least two protein subunits