论文部分内容阅读
目的分析住院2型糖尿病患者下肢血管病变发生情况及相关危险因素。方法对2009年1～12月882例住院2型糖尿病患者,伴下肢血管病变患者94例(102次住院)患者的性别、年龄、糖尿病病程、血压、空腹血糖、糖化血红蛋白(HbA1c)、血脂和糖尿病慢性并发症等进行分析。结果住院2型糖尿病下肢血管病变与年龄、性别、糖尿病病程和大、微血管并发症以及血脂质异常等明显相关。结论糖尿病下肢血管病变的病理变化主要是动脉粥样硬化,表现为血管内膜和中层厚度增加、斑块形成和钙化。病变的发生与长期慢性高血糖、高血压、血脂质代谢异常和内皮细胞功能紊乱等多种因素相关。早期血糖、血压和血脂质的良好控制,可以延缓并发症的发生和发展。踝肱指数(AB I)测量和双下肢血管彩色多普勒超声检查,可提供糖尿病患者下肢血管病变早期无创性检查的诊断依据。
Objective To analyze the incidence of lower extremity vascular lesions and related risk factors in hospitalized type 2 diabetic patients. Methods From January to December 2009, 882 hospitalized patients with type 2 diabetes mellitus and 94 patients with lower extremity vascular disease (102 hospitalizations) were analyzed for gender, age, duration of diabetes, blood pressure, fasting blood glucose, HbA1c, Chronic complications of diabetes and other analysis. Results The incidence of lower extremity vascular disease in hospitalized type 2 diabetic patients was significantly related to age, sex, duration of diabetes, macrovascular complications, and dyslipidemia. Conclusion The pathological changes of diabetic lower extremity vascular lesions are mainly atherosclerosis, which is characterized by an increase in intima-media thickness and plaque formation and calcification. Pathogenesis and long-term chronic hyperglycemia, hypertension, dyslipidemia and endothelial dysfunction and other factors related. Early blood glucose, blood pressure and lipid lipids in good control, can delay the occurrence and development of complications. Ankle brachial index (ABI) measurement and bilateral lower extremity vascular color Doppler ultrasound can provide the basis for the diagnosis of lower extremity vascular lesions in patients with noninvasive early detection of diabetes.