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目的:比较顺铂联合氟尿嘧啶、亚叶酸钙时辰化疗方案与常规化疗方案治疗进展期胃癌的临床疗效及不良反应。方法:将62例胃癌患者随机分为时辰化疗组(32例)和对照组(30例),两组均采用顺铂联合氟尿嘧啶、亚叶酸钙方案治疗。结果:时辰化疗组与常规化疗组的有效率分别为53.1%、37.5%,两组比较差异有统计学意义(P<0.05);不良反应发生率分别为34.4%、56.7%,两组比较差异有统计学意义(P<0.05)。结论:顺铂联合氟尿嘧啶时辰化疗方案治疗进展期胃癌疗效显著,毒性反应降低,患者的生活质量得以提高。
Objective: To compare the clinical efficacy and side effects of cisplatin combined with 5-fluorouracil and leucovorin chemotherapy in patients with advanced gastric cancer and conventional chemotherapy. Methods: Sixty-two patients with gastric cancer were randomly divided into two groups: the chemotherapy group (32 cases) and the control group (30 cases). Both groups were treated with cisplatin plus fluorouracil and leucovorin. Results: The effective rates of Chemotherapy group and conventional chemotherapy group were 53.1% and 37.5%, respectively, with significant difference between the two groups (P <0.05). The incidence rates of adverse reactions were 34.4% and 56.7% respectively. There was significant difference between the two groups There was statistical significance (P <0.05). Conclusion: The combination chemotherapy of cisplatin and fluorouracil hourly chemotherapy is effective in treating advanced gastric cancer, and the toxic reaction is reduced. The quality of life of the patients is improved.