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应用放免法测定38例新生儿肺炎患儿血浆内皮素(ET)及26例尿表皮生长因子(EGF),结果显示,急性期血浆ET及尿EGF与对照组比较差异非常显著(P均<0.01),8例重症肺炎急性期与恢复期比较,急性期血浆ET及尿EGF均高于恢复期,差异非常显著(P<0.01),血浆ET及尿EGF在病程中的变化规律相一致,两者呈正相关系(r=0.481,P<0.05)。提示测定血浆ET及尿EGF可作为判断新生儿肺炎病情变化的参考指标。
The plasma endothelin (ET) and 26 cases of urine epidermal growth factor (EGF) in 38 cases of neonatal pneumonia were detected by radioimmunoassay. The results showed that there was significant difference in plasma ET and urinary EGF between acute phase and control group (all P <0.01 ), 8 cases of severe pneumonia acute phase and recovery phase, acute plasma ET and urinary EGF were higher than the recovery period, the difference was significant (P <0.01), plasma ET and urinary EGF in the course of the course of the change consistent Who had a positive correlation (r = 0.481, P <0.05). Prompt determination of plasma ET and urinary EGF can be used as a reference indicator to determine changes in neonatal pneumonia.