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血红蛋白 Q-Thailand(HbQ-Thailand,HbQ)是一种慢速异常血红蛋白,其α链 N 端第74位天冬氨酸被组氨酸取代。首先由 Vella等在一华侨家庭中发现,继后在我国台湾省)和大陆以及泰国等地均有发现。由于 HbQ 在探讨α-珠蛋白基因的存在形式和突变发生的分子基础以及群体遗传研究方面的价值,长期来一直为学者所关注。1980年,我国开展了大规模的血红蛋白病普查,从全国许多省市送至上海市儿童医院医学遗传研究室鉴定
Hemoglobin Q-Thailand (HbQ-Thailand, HbQ) is a slow-onset abnormal hemoglobin whose histidine at position 74 of the N-terminal of the α-chain is replaced by histidine. First discovered by Vella et al in an overseas Chinese family, then in Taiwan Province of our country) and in mainland China and Thailand. As HbQ has been attracting scholars’ attention for a long time, the molecular basis of the occurrence and mutation of α-globin gene and the value of population genetic research are discussed. In 1980, China carried out a large-scale screening of hemoglobin disease, from many provinces and cities to Shanghai Children’s Hospital Medical Genetics laboratory identification