论文部分内容阅读
51例反流性食管炎病人,停止药物治疗至少2周后,随机分成2组,分别接受奥美拉佐60mg,每日1次(A组)或雷尼替丁150mg,每日2次(B组),进行双盲试验。治疗4周后重新进行镜检评价,未愈合者继续治疗,于第8周后再次评定。仍未治愈者更换药物继续试验4～8周。分析患者试验前、后2、4和8周的症状。结果表明,4周后愈合者(食管炎变成0或1级),A组25例占19例(76%),B组26例中占7例(27%),两组愈合率有明显的统计学差异(P=0.002);8周后的愈合率,A组为88%(22/25),B组为38%(10/26),两组差异更明显(P=0.001)。A组溃疡性食管炎(3级)的疗效比B组显著优越。8周后仍未
51 patients with reflux esophagitis, stopping drug treatment at least 2 weeks later, were randomly divided into two groups were received omerazepam 60mg, day 1 (A group) or ranitidine 150mg, 2 times a day ( B group), double-blind test. After 4 weeks of treatment, the microscopic examination was re-evaluated, and those who did not heal continued treatment and were re-evaluated after the 8th week. Still not cured to replace the drug to continue testing for 4 to 8 weeks. Symptoms were analyzed before, 2, 4, and 8 weeks after the patient’s test. The results showed that after 4 weeks, the healed (esophagitis became 0 or 1 grade), 25 cases in group A accounted for 19 cases (76%), 7 cases (27%) in group B, the healing rate was significantly (P = 0.002). The healing rate after 8 weeks was 88% (22/25) in group A and 38% (10/26) in group B, with a significant difference between the two groups (P = 0.001). A group of ulcerative esophagitis (grade 3) was significantly superior to the B group. Not yet after 8 weeks