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Objectives To valuate the therapeutic effect of tibia ＆ fibula fractures with interlocking intramedullary nailing and affect of systematic rehabilitation in postoperative treatment. Methods 26 cases that had tibia fractures were treated with interlocking intramedullary nailing and were given early systematic rehabilitation postoperatively. Results The average follow up periods were 9.2 months (range 4～ 20 m). Range of motion of the joints and myodynamia of the affected limbs were normal in all patients after 2 weeks post discharge. The results were 21 excellent, 4 good and 1 fair valuated according to Johner Wruh method. Conclusions The results of interlocking intramedullary nailing are excellent while combined the methods of unreamed nailing, static fixation, early mobilization and late weight loading with the early and systematic rehabilitation postoperatively.