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手术、放疗和化疗已使儿童肿瘤患者的死亡率降至50%以下,文献报道成人肿瘤患者大剂量化疗的副作用是卵巢功能障碍,如月经过少或闭经及更年期机能缺失现象。本文51例年龄为2月～17岁(平均6.1岁);化疗5月～9年(平均1.1年)。42例治疗中及治疗后明显直线的生长。22例测定促卵泡素(FSH)、促黄体生成素(LH)、生乳素(PRL)、孕酮(P)及雌二醇(E_2)血清值。9例有月经周期的幼女,在周期的第5、21及26天检查上述激素。放免测定血清值:FSH2.7～31.2mIU/ml 7.5%;LH22～45.7mIU/ml 9.3%;PRL70.5～μIU/ml 9.1%。
Surgery, radiotherapy and chemotherapy have reduced the mortality rate of children with cancer to less than 50%. The side effects of high-dose chemotherapy in adult patients with cancer are ovarian dysfunction, such as menorrhagia or menopause and menopause. This article 51 cases of age from February to 17 years (mean 6.1 years); chemotherapy from May to 9 years (mean 1.1 years). 42 cases of treatment and after treatment significantly linear growth. Twenty-two subjects were tested for the serum levels of FSH, LH, PRL, P and E2. Nine young girls with menstrual cycle, check the above hormones on the 5th, 21st and 26th days of the cycle. Serum radioimmunoassay: FSH2.7 ~ 31.2mIU / ml 7.5%; LH22 ~ 45.7mIU / ml 9.3%; PRL70.5 ~ μIU / ml 9.1%.