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目的探讨川崎病患儿冠状动脉损伤与血浆可溶型不规则趋化因子(s FKN)的关系。方法选取2015年2月至2017年2月在南京医科大学附属淮安第一医院治疗的43例川崎病患儿为研究对象,其中有冠状动脉损伤患儿16例(冠脉损伤组),无冠状动脉损伤患儿27例(无冠脉损伤组),同时选取40例健康儿童作为对照组,检测各组血常规、生化指标、s FKN以及冠状动脉内径。结果冠脉损伤组和无冠脉损伤白细胞计数(WBC)、C反应蛋白(CRP)、红细胞沉降率(ESR)、血小板计数(PLT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、s FKN和冠状动脉内径D值明显高于对照组(P<0.05);冠脉损伤组ESR、PLT、s FKN和冠脉内径明显高于无冠脉损伤组(P<0.05);血浆s FKN与ESR、冠状动脉内径D值呈正相关(r=0.404和0.389,P<0.05)。结论血浆s FKN与川崎病患儿冠状动脉损伤有一定关系,其可能促进冠状动脉损伤的发生发展,值得进一步研究。
Objective To investigate the relationship between coronary artery injury and plasma soluble soluble chemotactic factor (s FKN) in children with Kawasaki disease. Methods A total of 43 children with Kawasaki disease were enrolled in the First Affiliated Hospital of Nanjing Medical University from February 2015 to February 2017. Among them, 16 children with coronary artery injury (coronary artery injury group) and no coronary artery disease Twenty-seven children with arterial injury (no coronary artery injury group) were enrolled. Forty healthy children were selected as control group. Blood routine, biochemical parameters, s FKN and coronary artery diameter were measured. Results WBC, C reactive protein (CRP), erythrocyte sedimentation rate (ESR), platelet count (PLT), prothrombin time (PT), fibrinogen (FIB) , S FKN and the diameter of coronary artery D were significantly higher than those of the control group (P <0.05). The levels of ESR, PLT, s FKN and coronary diameter were significantly higher in patients with coronary artery injury than those without coronary artery disease (P <0.05) FKN was positively correlated with ESR and coronary artery diameter D (r = 0.404 and 0.389, P <0.05). Conclusion There is a relationship between plasma s FKN and coronary artery injury in children with Kawasaki disease, which may promote the occurrence and development of coronary artery injury and deserve further study.