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目的探讨儿童及青少年卵巢肿瘤的发病特点、病理类型与发病年龄的关系,并评价其诊治手段及预后因素。方法选取1980年1月-2005年12月在中山大学肿瘤防治中心治疗并确诊的儿童及青少年卵巢肿瘤患儿187例,并对其临床及随访资料进行回顾性分析。采用SPSS 13.0统计软件,定性变量比较采用χ2检验,生存率计算用寿命表法。采用Kaplan-Meier法进行生存分析。结果 187例卵巢肿瘤中良性56例,恶性119例,交界性12例。不同病理类型的卵巢肿瘤与患儿发病年龄有一定关系(χ2=12.396,P=0.015)。187例卵巢肿瘤中,56例良性肿瘤5 a总生存率为98%,119例恶性肿瘤5 a总生存率为76%,12例交界性肿瘤5 a生存率为83%。单因素生存分析显示,影响总生存时间的危险因素为肿瘤分期、是否行规范化疗和化疗方案。结论超声及CT是卵巢肿瘤诊断的主要方法。不同病理类型的儿童卵巢肿瘤与发病年龄有一定关系。肿瘤分期、术后辅助治疗方式均影响患儿总生存时间。
Objective To investigate the incidence of ovarian tumors in children and adolescents, the relationship between pathological types and age of onset, and to evaluate the diagnosis and treatment methods and prognostic factors. Methods A total of 187 children with adolescent ovarian cancer who were diagnosed and treated at Cancer Center of Sun Yat-sen University from January 1980 to December 2005 were selected and their clinical and follow-up data were retrospectively analyzed. Using SPSS 13.0 statistical software, qualitative variables were compared using χ2 test, survival rate was calculated using life table method. Survival analysis was performed using Kaplan-Meier method. Results Among 187 ovarian tumors, 56 were benign, 119 were malignant and 12 were borderline. Different pathological types of ovarian cancer and the age of onset of children have a certain relationship (χ2 = 12.396, P = 0.015). In 187 cases of ovarian tumors, 56 cases of benign tumors 5 a total survival rate was 98%, 119 cases of malignant tumors 5 a total survival rate of 76%, 12 cases of borderline tumors 5 a survival rate of 83%. Univariate survival analysis showed that the risk factors affecting the overall survival time were tumor stage, whether standard chemotherapy and chemotherapy regimen. Conclusion Ultrasound and CT are the main methods of ovarian cancer diagnosis. Different pathological types of children with ovarian cancer and age have a certain relationship. Tumor staging, postoperative adjuvant therapy affect the overall survival of children.