吗啡依赖和戒断大鼠某些脑核团中β-内啡肽含量的变化

• 作 者: 叶晓明 王新华 李家乐 石学银
• 机 构: 第二军医大学长征医院麻醉科!上海200003,第二军医大学长征医院麻醉科!上海200003,第二军医大学长征医院麻醉科!上海200003,第二军医大学长征医院麻醉科!上海200003
• 出 处: 中国疼痛医学杂志
• 发表日期: 1999年04期
• 关键词: 吗啡依赖 β-内啡肽 核团 戒断症状 阿片依赖 脑区 腹侧被盖区 蓝斑核 下丘脑弓状核 鼠脑

为探讨阿片依赖和戒断的神经生物学机制,本研究观察了吗啡依赖和戒断对大鼠脑内与奖赏效应及戒断症状有关核团中β内啡肽(βEP) 含量的影响。结果:(1)吗啡依赖大鼠伏隔核(Acc) 、中脑导水管周围灰质(PAG) 、蓝斑核(LC) 和下丘脑弓状核(ARH) 的βEP含量显著低于正常对照组( P < 0 .05 或0 .01) 。(2) 吗啡戒断大鼠Acc 和ARH 的βEP含量与依赖组比较无显著差异,仍显著低于正常对照组( P< 0 .05 或0 .01) ;而VTA( 腹侧被盖区) 、PAG 和LC 的βEP 含量较依赖组显著升高( P< 0 .05) ,与正常对照组比较无显著差异。结论:吗啡依赖和戒断时脑内与奖赏效应及戒断症状有关的一些核团中β内啡肽含量发生了改变。

In order to explore the neurobiological mechanisms of opiate dependence and withdrawal, we investigated the effects of morphine dependence and withdrawal on the content of β-endorphin (βEP) in the nucleus of reward and withdrawal symptoms in rats influences. Results: (1) The content of βEP in morphine-dependent rat nucleus accumbens (Acc), periaqueductal gray (PAG), locus coeruleus (LC) and hypothalamic arcuate nucleus (ARH) Control group (P <0.05 or 0.01). (2) The contents of βEP in Acc and ARH of morphine withdrawal rats were not significantly different from those in dependent group, but still significantly lower than those in normal control group (P <0.05 or 0.01) ), PAG and LC βEP content was significantly higher than the dependent group (P <0 .05), compared with the normal control group no significant difference. CONCLUSIONS: The content of β-endorphin in some nuclei associated with reward effects and withdrawal symptoms in the brain during morphine dependence and withdrawal was altered.