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目的:探讨D型人格与脑小血管病（cerebral small vessel disease, CSVD）患者脑白质高信号（white matter hyperintensities, WMHs）严重程度的相关性。方法:前瞻性连续纳入2020年11月至2021年6月期间在常州市第一人民医院住院的CSVD患者。在入院时对患者进行D型人格量表评分，分别计算消极情感（negative affectivity, NA）和社会抑制（social inhibition, SI）维度的分值，并采集患者一般资料、实验室检查资料及影像学资料。使用Fazekas视觉评分法对患者脑室周围及深部WMHs进行评分，总分0~2分定义为低分级WMHs（low WMHs,L-WMHs），3~6分定义为高分级WMHs（high WMHs, H-WMHs）。应用多变量n logistic回归分析确定WMHs的独立影响因素。n 结果:共纳入100例CSVD患者，男性51例（51%），年龄（67.21±9.38）岁；29例（29%）存在D型人格；L-WMHs组56例（56%），H-WMHs组44例（44%）。单变量分析显示，H-WMHs组D型人格比例、NA维度评分、高血压比例、舒张压以及甘油三酯和高半胱氨酸水平均显著高于L-WMHs组（n P均<0.05）。多变量logistic回归分析显示，NA维度评分[优势比（odds ratio,n OR）18.351，95%置信区间（confidence interval, n CI）2.780~121.135；n P=0.003]、年龄（n OR 1.134，95% n CI 1.039~1.238；n P=0.005）和高血压（n OR 7.771，95% n CI 1.525~39.607；n P=0.014）与WMHs严重程度存在显著正相关联系，而甘油三酯与WMHs严重程度存在显著负相关联系（n OR 0.306，95% n CI 0.130~0.722；n P=0.007）。n 结论:D型人格与CSVD患者的WMHs严重程度密切相关。“,”Objective:To investigate the correlation between the Type D personality and the severity of white matter hyperintensities (WMHs) in patients with cerebral small vessel disease (CSVD).Methods:Consecutive patients with CSVD admitted to the Changzhou First People\'s Hospital between November 2020 and June 2021 were enrolled prospectively. The patients were scored on the Type D Personality Scale at admission; the scores of negative affectivity (NA) and social inhibition (SI) dimension were calculated respectively. The general data, laboratory examination data and imaging data of the patients were collected. Periventricular and deep WMHs were scored using the Fazekas visual scoring method. The total score 0-2 was defined as low-WMHs (L-WMHs), and 3-6 was defined as high-WMHs (H-WMHs). Multivariaten logistic regression analysis was used to determine the independent influencing factor of WMHs.n Results:A total of 100 patients with CSVD were enrolled, including 51 males (51%), aged 67.21±9.38 years, 29 (29%) had Type D personality; 56 (56%) were in the L-WMHs group and 44 (44%) were in the H-WMHs group. Univariate analysis showed that the proportion of Type D personality, NA dimension score, the proportion of hypertension, diastolic blood pressure, triglyceride and homocysteine in the H-WMHs group were significantly higher than those in the L-WMHs group (all n P<0.05). Multivariaten logistic regression analysis showed that NA dimension score (odds ratio [n OR] 18.351, 95% confidence interval [n CI] 2.780-121.135; n P=0.003), age (n OR 1.134, 95% n CI 1.039-1.238; n P=0.005) and hypertension (n OR 7.771, 95% n CI 1.525-39.607; n P=0.014) were significantly positively correlated with the severity of WMHs, while triglycerides were significantly negatively correlated with the severity of WMHs (n OR 0.306, 95% n CI 0.130-0.722; n P=0.007).n Conclusion:Type D personality is closely associated with the severity of WMHs in patients with CSVD.