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目的：探讨阿奇霉素序贯治疗肺炎支原体肺炎患儿的临床效果及其对促炎因子的影响。方法选取2012年4月至2014年2月我院收治的肺炎支原体肺炎患儿90例，随机分为对照组40例与观察组50例，观察组患儿给予阿奇霉素序贯治疗，对照组患儿给予乳糖红霉素治疗，比较两组患儿的临床效果及其促炎因子的变化情况。结果经治疗后，观察组患儿总有效率为98.0%，明显优于对照组的62.5%；观察组患儿血清内促炎因子高敏C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）及肿瘤坏死因子α（TNF-α）水平较治疗前均明显降低，且观察组患儿血清hs-CRP及TL-6水平降低幅度明显高于对照组，差异均有统计学意义（均P＜0.05）。结论肺炎支原体肺炎患儿采用阿奇霉素序贯治疗，可明显提高治疗效果，降低炎性因子水平，缩短治疗时间。“,”Objective To investigate the clinical effect of Azithromycin Sequential Therapy in the treatment of mycoplasma pneumonia in children and its effect on proinflammatory cytokine.Methods 90 cases of mycoplasma pneumonia from 2012 April to 2014 February in our hospital,were randomly divided into control group 40 cases and observation group of 50 cases,the observation group were given Azithromycin Sequential therapy,the control group were given erythromycin treatment,the changes of two groups were compared the clinical treatment effect and proinflammatory cytokine.Results After treatment,the observation group with total effective rate was 98.0%, significantly better than the control group 62.5%;the observation group with serum proinflammatory cytokine High- sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6) and tumor necrosis factor alpha(TNF-alpha) levels were significantly lower than before treatment,and the observation group serum hs-CRP and TL-6 level is significantly higher than that in the control group,the difference was statisticaly significant(P<0.05).Conclusion Children with mycoplasmal pneumonia with Azithromycin Sequential therapy,can significantly improve the therapeutic effect,reduce the level of inflammatory factors,shorten the treatment time.