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Background:Spontaneous potentials in electromyography (EMG) ofparaspinal muscles are associated with diaphragm denervation and,therefore,poor respiratory function in amyotrophic lateral sclerosis (ALS) is understandable.EMG changes in the rectus abdominis (RA)display an effect similar to those in paraspinal muscles with respect to the function of lower motor neurons in the thoracic spinal cord.The RA denervation was examined to determine its association with ventilation dysfunction in ALS.Methods:We collected the clinical data of 128 patients with sporadic ALS in Department of Neurology of Peking University Third Hospital from 2009 to 2013.EMG,Revised ALS Functional Rating Scale (ALSFRS-R) and forced vital capacity (FVC) were performed in all patients and the differences in the EMG changes in RA between those with and without FVC ≥ 80％ were analysed.Results:The mean FVC value was 83.4％ ± 17.1％ (range:45％-131％) of the predicted value.A total of 79 patients displayed FVC ≥80％,and 49 patients displayed FVC ＜80％.Compared with the patients displaying a normal FVC (60/79,75.9％),spontaneous activity in RA was significantly different among those patients displaying an FVC ＜80％ (47/49,95.9％).In addition,spontaneous potentials in RA were more frequently detected in patients exhibiting dyspnea (32/33,97.0％) than in patients without dyspnea (75/95,78.9％).Conclusion:Spontaneous potentials in RA are associated with ventilation dysfunction and dyspnea in ALS patients.