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作者观察前列腺素 E_1治疗5例急性心肌梗塞伴左心衰竭病人的血流动力学效果,其中男性3例,女性2例,年龄46～72(平均64)岁,均在急性心肌梗塞和左心功能衰竭后12小时内用前列腺素 E_1静脉滴注,观察前列腺素 E_1静脉滴注后的血流动力学效果。前列腺素 E_1的浓度为0.4μg/ml,最快滴注速度为0.021μg/kg/min,滴注时间为90min。结果:心率无明显增加;平均动脉压和体循环阻力明显降低;肺楔状压自21±3下降至15±1 mmHg(P<0.05);平均肺动脉压和肺血管阻力降低(P<0.05);心脏指数自2.38±0.08增加至2.89±0.58 L/min/M~2(P<0.01);每搏容量自51±17增至59±20 ml/beat
The authors observed the hemodynamic effects of prostaglandin E_1 in 5 patients with acute myocardial infarction and left ventricular failure, including 3 males and 2 females, aged 46 to 72 (mean, 64 years) with acute myocardial infarction and left heart Intravenous infusion of prostaglandin E_1 within 12 hours after failure was used to observe the hemodynamic effects of intravenous infusion of prostaglandin E_1. Prostaglandin E_1 concentration of 0.4μg / ml, the fastest infusion rate of 0.021μg / kg / min, infusion time of 90min. Results: Heart rate did not increase significantly; average arterial pressure and systemic resistance decreased significantly; pulmonary wedge pressure decreased from 21 ± 3 to 15 ± 1 mmHg (P <0.05); mean pulmonary artery pressure and pulmonary vascular resistance decreased (P <0.05) The index increased from 2.38 ± 0.08 to 2.89 ± 0.58 L / min / M ~ 2 (P <0.01). The stroke volume increased from 51 ± 17 to 59 ± 20 ml / beat