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目的：探讨原发性鼻腔、鼻窦恶性黑色素瘤的诊断和治疗方法。方法：对8例该类患者的临床资料进行回顾性分析。结果：病理形态以多种细胞类型和组织形态混合存在为主要特点，无色素型黑色素瘤S－100蛋白均阳性。所有患者均得到手术治疗且切缘阴性。术后加放疗6例，复发3例，复发灶与原发病灶同侧，复发时间在术后1年左右。1年和2年生存率分别为75％和62％。2例生存期超过5年，均系手术加放疗者。结论：S－100蛋白是无色素型黑色素瘤的重要标志物，术后放疗的患者生存期较长，手术切缘阴性并不提示良好的预后。
Objective: To investigate the diagnosis and treatment of primary nasal and nasal malignant melanoma. Methods: The clinical data of 8 patients were retrospectively analyzed. Results: The pathological features were characterized by the mixed existence of many cell types and histomorphological features. The positive staining of S-100 protein was found in non-pigmented melanoma. All patients were surgically treated and had negative margins. Postoperative radiotherapy in 6 cases, 3 cases of recurrence, recurrence and ipsilateral primary lesion, recurrence time in about 1 year after surgery. The 1-year and 2-year survival rates were 75% and 62% respectively. 2 cases of survival of more than 5 years, are surgery plus radiotherapy. Conclusion: The S-100 protein is an important marker of amelanotic melanoma. Patients who underwent postoperative radiotherapy had longer survival period and negative surgical margin did not suggest a good prognosis.