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目的观察中药口服联合大黄乌梅合剂高位保留灌肠结合西医常规疗法治疗乙型肝炎肝衰竭的临床疗效。方法将50例乙型肝炎肝衰竭患者随机分为试验组和对照组各25例,对照组给予西医常规治疗,试验组除西医常规治疗外,同时给予大黄乌梅合剂高位保留灌肠(3-4周)和中药辨证治疗(7-8周);观察临床疗效及治疗前、治疗4周和治疗8周肝功能、凝血功能和高迁移率族蛋白B1(HMGB1)的变化情况。结果试验组总有效率为44.0%,对照组为28.0%,组间疗效差异有统计学意义(P<0.05)。两组治疗4周后ALT、ALB、PT、PAT和HMGB1差异有统计学意义(P<0.05,P<0.01),治疗8周后ALT、TB IL、PT、PAT和HMGB1差异有统计学意义(P<0.05,P<0.01)。结论中药口服加高位保留灌肠结合西医常规疗法治疗乙型肝炎肝衰竭临床疗效良好。
Objective To observe the clinical curative effect of traditional Chinese medicine combined with rhubarb and umemus mixture on high retention enema and western medicine routine therapy in treatment of hepatitis B liver failure. Methods Fifty patients with hepatic failure of hepatitis B were randomly divided into experimental group and control group, 25 cases in each group. The control group was treated with conventional western medicine. In addition to conventional western medicine treatment, the experimental group was given high retention enema of Rhubarb WuMei mixture (3-4 weeks ) And traditional Chinese medicine (7-8 weeks). The clinical curative effect and changes of liver function, coagulation function and high mobility group box 1 (HMGB1) before treatment, 4 weeks and 8 weeks of treatment were observed. Results The total effective rate was 44.0% in the experimental group and 28.0% in the control group. There was significant difference in the efficacy between the two groups (P <0.05). There were significant differences in ALT, ALB, PT, PAT and HMGB1 between the two groups after 4 weeks of treatment (P <0.05, P <0.01) P <0.05, P <0.01). Conclusion Chinese medicine plus high retention enema combined with Western conventional therapy for the treatment of hepatitis B liver failure with good clinical efficacy.