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目的:文献研究和民间调查钩吻的临床应用,并探讨解钩吻毒的实验研究。方法:取新鲜羊血、猪血、鸭血及与钩吻总碱的混合液,根据Dm的TAG灌胃给药小鼠的解毒量效关系与特异性,观察小鼠中毒及死亡情况。结果:当羊血与TAG最低全部致死量给药体积为4∶1时,小鼠能全部存活,比例再低时出现小鼠死亡现象。猪血和鸭血也存在解钩吻毒的效力,羊血解钩吻毒缺少特异性。结论:(1)民间存在应用钩吻防治恶性肿瘤、肝硬化腹水及部分关节病变的现象,并具有一定疗效。(2)羊血、猪血、鸭血解钩吻毒是客观存在的。
OBJECTIVE: To investigate the clinical application of hook-kiss in literature research and folk investigation and to explore the experimental study on kissing toxin. Methods: Take fresh sheep blood, pig blood, duck blood and total alkaloids mixed with hook kiss, according to Dm’s TAG intragastric administration detoxification dose-effect relationship and specificity to observe the mice poisoning and death. Results: When the lowest lethal dose of sheep blood and TAG was 4:1, the mice survived completely. When the ratio was lower, the mice died. Pig blood and duck blood also exist in the efficacy of kissing poison, sheep blood kiss toxin lack of specificity. Conclusions: (1) There is a non-governmental application of kyphosis to prevent and treat malignant tumors, cirrhosis, ascites and some joint diseases, and has certain curative effect. (2) Sheep blood, pig blood, duck blood hook kiss poison is an objective reality.