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The concentration of plasma endothelin (ET) was measured by radio immuno assay (RIA) technique in 21 healthy adults.The diameter of microvascular in nasal mucosal and number of microvascular bulbform were also observed by microcirculation microscopy.Results showed that the mean value of ET concentration was 55 88±9 36pg/ml,and the mean value of diameter of microvascular in nasal mucosal was 20 06±0 90μm.With correlation analysis,the linear correlation equation was Y=23 166-0 056X,the coefficient of correlation was -0 578,P<0 01.The mean number of microvascular bulbform was 20 71±6 35.With correlation analysis to the ET concentration of plasma,the linear correlation equation was Y=39 14-0 33X,the coefficient of correlation was -0 486,P<0 05.These results indicated that there were negative correlation between concentration of plasma endothelin and diameter of nasal mucosal microvascular and number of microvascular bulbform.It was suggested that the plasma endothelin has obvious regulation effect on nasal mucosal microvascular. [Chinese Arch Otolaryngol Head Neck Surg,2000;7(4):202~204 From the Department of Otolaryngology,Secand People’s Hospital of Foshan City,Guangdong Foshan 528000 (Dr.Chen Shuhua)]
The concentration of plasma endothelin (ET) was measured by radio immuno assay (RIA) technique in 21 healthy adults. The diameter of microvascular in nasal mucosal and number of microvascular bulbform was also observed by microcirculation microscopy. Results showed that the mean value of ET concentration was 55 88 ± 9 36 pg / ml, and the mean value of diameter of microvascular in nasal mucosal was 20 06 ± 0 90 μm. With correlation analysis, the linear correlation equation was Y = 23 166-0 056X, the coefficient of correlation was -0 578, P <0 01. The mean number of microvascular bulbform was 20 71 ± 6 35.With correlation analysis to the ET concentration of plasma, the linear correlation equation was Y = 39 14-0 33X, the coefficient of correlation was -0 486, P <0 05.These results indicated that were were negative correlation between concentration of plasma endothelin and diameter of nasal mucosal microvascular and number of microvascular bulbform. It was suggested that the plasma [Chinese Arch Otolaryngol Head Neck Surg, 2000; 7 (4): 202 ~ 204 From the Department of Otolaryngology, Sec and People’s Hospital of Foshan City, Guangdong Foshan 528000 (Dr. Chen Shuhua) ]