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作者研究12例有蛋白尿的胰岛素依赖性糖尿病肾病患者,并与12名健康人对照。用放射免疫法测定血浆β_2-微球蛋白,并测定肌酐、反肌酐(1/肌酐浓度×10~3)浓度及肌酐清除率,将结果与用 ~(51)Cr-EDTA测定的肾小球滤过率(GFR)对照。12例糖尿病肾病患者血浆β_2-微球蛋白浓度与GFR 之间有极明显的负相关关系(r=-0.96;P<0.001),患者的 GFR 均低于80ml/min/1.73m~2,而血浆β_2-微球蛋白浓度则超过正常对照组的最高值((?)±SEM 1.5±0.09mg/L)。β_2-微球蛋白浓度与
The authors studied 12 patients with insulin-dependent diabetic nephropathy with proteinuria and compared with 12 healthy individuals. Plasma β 2 -microglobulin was measured by radioimmunoassay. Creatinine, anti-creatinine (1 / creatinine concentration × 10-3) and creatinine clearance were measured. The results were compared with those measured by ~ (51) Cr-EDTA Filtration rate (GFR) control. There was a significant negative correlation between plasma β 2-microglobulin concentration and GFR in 12 patients with diabetic nephropathy (r = -0.96; P <0.001). GFR in patients with diabetic nephropathy was lower than 80ml / min / 1.73m 2 Plasma β 2 -microglobulin concentration was higher than the normal control group ((±) ± SEM 1.5 ± 0.09mg / L). β_2-microglobulin concentration and