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目的观察并探讨多西他赛(Docetaxel,DCT)与顺铂(Cisplatin,CDDP)联合行不同化疗途径对宫颈癌(cervical cancer,CC)的有效性和安全性。方法宁波市第一医院于2010年5月—2014年7月期间对确诊为CC的90例患者实施化疗,其中45例接受DCT联合CDDP静脉化疗,为对照组,另外45例采用DCT联合CDDP动脉灌注化疗(arterial infusion chemotherapy,AIC),作为观察组。评价2组患者的近期疗效,并随访化疗后宫旁缓解、化疗后手术、中心复发以及不良反应发生情况。结果观察组有效率为91.1%(41/45),对照组为80.0%(36/45),观察组有效率明显高于对照组(P<0.05);观察组化疗后宫旁缓解率、化疗后手术率、中心复发率分别为82.2%(37/45)、75.6%(34/45)和4.4%(2/45),对照组为66.7%(30/45)、73.3%(33/45)和4.4%(2/45),观察组化疗后宫旁缓解率明显高于对照组,而2组一年内化疗后手术率及中心复发率相比,差异无统计学意义(P>0.05);观察组骨髓抑制、胃肠道反应、神经毒性发生率明显低于对照组(P<0.05)。结论 DCT联合CDDP的动脉灌注化疗治疗CC具有良好的近期疗效,且不良反应发生率均更低,是CC较为安全有效的疗法。
Objective To investigate the efficacy and safety of different chemotherapy regimens in patients with cervical cancer (CC) treated with docetaxel (DCT) and cisplatin (CDDP). Methods From January 2010 to July 2014, 90 cases of patients with definite CC were treated with chemotherapy in Ningbo First Hospital. Among them, 45 cases received DCT combined with CDDP intravenous chemotherapy as the control group, while the other 45 cases received DCT combined with CDDP artery Infusion chemotherapy (arterial infusion chemotherapy, AIC), as the observation group. Evaluation of the short-term efficacy of two groups of patients and follow-up chemotherapy after uterine paralysis, chemotherapy after surgery, central recurrence and adverse reactions. Results The effective rate was 91.1% (41/45) in the observation group and 80.0% (36/45) in the control group. The effective rate in the observation group was significantly higher than that in the control group (P <0.05) The rates of operation and center recurrence were 82.2% (37/45), 75.6% (34/45) and 4.4% (2/45), respectively. The control group was 66.7% (30/45) and 73.3% (33/45) And 4.4% (2/45) respectively. The paracancerous remission rate in the observation group was significantly higher than that in the control group. There was no significant difference between the two groups in the postoperative rates of chemotherapy and the center recurrence rate within one year (P> 0.05) The incidence of bone marrow suppression, gastrointestinal reaction and neurotoxicity were significantly lower in the control group (P <0.05). Conclusion The combination of DCT and CDDP with arterial infusion chemotherapy has a good short-term curative effect and a lower incidence of adverse reactions. It is a safe and effective treatment for CC.