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很多实验证明T 细胞对免疫应答中所产生的Ig 种类起着决定性作用,而且这种作用多是通过分泌各种可溶性免疫因子如白细胞介素实现的。IL-4即其中很有意思的一种。IL-4几乎对所有由造血于细胞分化来的细胞都有影响。通过体外B 细胞—LPS系统证实IL-4对IgG1及IgE 的产生也有重要调节作用。
Many experiments have shown that T cells play a decisive role in the type of Ig produced in the immune response, and this effect is mostly achieved through the secretion of various soluble immune factors such as interleukins. IL-4 is one of the most interesting ones. IL-4 affects almost all cells differentiated from hematopoietic cells. IL-4 also plays an important regulatory role on the production of IgG1 and IgE by in vitro B cell-LPS system.