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目的探讨β-catenin和Galectin-3蛋白在宫颈癌的表达及临床病理学意义。方法收集2010年1月-2013年6月间手术切除经病理证实为宫颈癌标本83例。采用免疫组织化学法检测83例宫颈癌组织、45例宫颈上皮内瘤变(CIN)及25例正常宫颈中β-catenin和Galectin-3的表达。结果 1在宫颈癌组织中β-catenin和Galectin-3阳性表达率分别为74.70%、81.93%,均显著高于CINⅠ、CINⅡ和正常宫颈组织(P<0.05);但在CINⅢ中的表达与在宫颈癌中的表达差异无统计学意义(P>0.05),三者合并后与宫颈癌比较差异有统计学意义(P<0.05)。2β-catenin蛋白的表达与患者年龄、肿瘤大小及病理类型无关(P>0.05),与组织学分级、国际妇产科联盟(FIGO)分期及淋巴结转移有关(P<0.05);Galectin-3蛋白的表达与患者年龄、FIGO分期、肿瘤大小及病理类型无关(P>0.05),与组织学分级及淋巴结转移有关(P<0.05)。3β-catenin和Galectin-3蛋白表达呈正相关(r=0.327,P=0.002)。结论宫颈癌组织中Galectin-3的高表达及β-catenin的高表达与宫颈癌的浸润、转移有关,并可能成为判断宫颈癌组织转移及预后的指标之一。
Objective To investigate the expression of β-catenin and Galectin-3 protein in cervical cancer and its clinicopathological significance. Methods Totally 83 cases of cervical cancer confirmed by pathology were collected from January 2010 to June 2013. The expressions of β-catenin and Galectin-3 in 83 cases of cervical cancer, 45 cases of cervical intraepithelial neoplasia (CIN) and 25 cases of normal cervix were detected by immunohistochemistry. Results 1 The positive rates of β-catenin and Galectin-3 in cervical cancer tissues were 74.70% and 81.93%, respectively, which were significantly higher than those in CINⅠ, CINⅡ and normal cervical tissues (P <0.05) There was no significant difference in the expression of cervical cancer (P> 0.05). There was significant difference between cervical cancer and cervical cancer (P <0.05). The expression of 2β-catenin was not associated with age, tumor size and pathological type (P> 0.05), but was related to histological grade, FIGO staging and lymph node metastasis (P <0.05). The expression of Galectin- (P> 0.05), but not with age, FIGO staging, tumor size and pathological type (P> 0.05), but also with histological grade and lymph node metastasis (P <0.05). There was a positive correlation between the expression of 3β-catenin and Galectin-3 (r = 0.327, P = 0.002). Conclusion The high expression of Galectin-3 and the high expression of β-catenin in cervical cancer are related to the infiltration and metastasis of cervical cancer, and may be one of the indicators to judge the metastasis and prognosis of cervical cancer.