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在接受 1 31 I内放射治疗分化型甲状腺癌和接受外放射治疗头颈部肿瘤后 ,部分病人出现口腔干燥症 ,影响病人吞咽、进食、营养和睡眠。氨磷汀是一种有机硫磷酸盐 ,其活化的代谢产物 WR- 10 65等可选择性地保护正常组织、减轻放 /化疗的毒性损害作用而不影响抗肿瘤作用。氨磷汀防护外放射损伤已有大量的临床研究 ,已被 FDA批准为用于减轻肿瘤患者因放疗引起的口干症的治疗药物。有关内放射损伤防护 ,氨磷汀的应用已取得了初步肯定的疗效 ,但在许多方面还值得进一步探讨
After receiving 131 I radiation treatment of differentiated thyroid cancer and external radiotherapy of head and neck cancer, some patients with xerostomia, affecting the patient swallowing, eating, nutrition and sleep. Amifostine is an organic sulfur phosphate, its active metabolite WR- 1065 and other optional protection of normal tissue, reduce the toxic effects of radiotherapy / chemotherapy without affecting the anti-tumor effect. Amifostine has been extensively studied in the field of protective external radiation injury and has been approved by the FDA as a therapeutic drug for reducing the incidence of dry mouth due to radiotherapy in cancer patients. The use of amifostine has yielded initial positive results regarding radiation injury protection, but it is worth further exploration in many aspects