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The experimental study is carded out on high-speed centrifugal pumps with three different impellers. The ex-perimental results and analysis show that high-speed centrifugal pumps with a closed complex impeller can achieve thehighest efficiency and the lowest head coefficient followed by those with half-open impeller and open-impeller, and canobtain much easily stable head-capacity characrastic curve, while those with a half-open complex impeller can’t. Thecharacteristic curve with a open impeller is almost constant horizontal line before dropping sharply. The results also showthat the axial clearance between pump casing and impeller can influence greatly on the performance of centrifugal pumps.