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河北省军区门诊部赵树桢:作者报告1例因上腹部疼痛不适服用胃复安、黄连素治疗引起锥体外系反应的患者,开始时出现心神不定、烦燥、双手微颤、头晕、视物晃动,继续服药至第3天上述症状加重,并出现牵嘴歪唇动作,自己不能控制。两腿绵软无力,时而出现下蹲,不能直立,时而两腿抖动。患者自动停药,上述症状逐渐缓解。黄连素无论是药理上和临床应用上证明无此副作用。作者认为胃复安能阻断纹状体苍白球多巴胺受体,而出现乙酰胆硷受体的优
Zhao Shizhen, Outpatient Department of Military Command of Hebei Province: The author reported 1 patient suffering from upper abdominal pain discomfort taking metoclopramide and berberine to treat patients with extrapyramidal reactions. At the beginning, he appeared unsure, irritated, both hands shaking, dizzy, , Continue to take medicine to the first 3 days of the above symptoms aggravated, and appear distorted lip movements, they can not control. Soft legs weakness, sometimes squatting, can not stand up, sometimes shaking his legs. Patients automatically withdrawal, the symptoms gradually eased. Berberine both pharmacological and clinical application proved no such side effects. The author believes that metoclopramide can block the striatum globus pallidis receptor, and the emergence of acetylcholine receptor excellent