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为了探讨羰基镍的细胞遗传学和血液学毒性,本文对86例羰基镍作业人员做了染色体畸变(CA)、姊妹染色单体互换(SCE)、淋巴细胞做核(MN)、中毒颗粒细胞(PGC)、网织红细胞、酸性磷酸酶(ACP)和碱性磷酸酶(ALP)活性的变化进行了测定。主要结果见表1、2。从表1、2可见,暴露组CA明显高于厂内、外对照组(P<0.05);中毒组CA、SCE、MN和PGC较暴露组和厂内、外对照组都明显增高(P<0.05)。从结果可以看出,事故组、痰检核异质组、发镍>2.2μg/g,各工龄组的暴露人员的CA、SCE和MN都高于厂外对照组(P<0.05);痰检核异质组
In order to investigate the cytogenetics and hematological toxicity of carbonyl nickel, 86 carbonyl nickel workers were investigated for chromosomal aberrations (CA), sister chromatid exchange (SCE), lymphocyte nuclei (MN), poisoned granulosa cells (PGC), reticulocyte, acid phosphatase (ACP) and alkaline phosphatase (ALP) activity were measured. The main results are shown in Tables 1 and 2. As can be seen from Table 1 and Table 2, the exposure group CA was significantly higher than that of the control group (P <0.05); CA, SCE, MN and PGC in the poisoning group were significantly higher than those in the exposed group and the control group (P < 0.05). From the results, it can be seen that CA, SCE and MN of exposed workers in each age group were higher than those in the control group (P <0.05) in accident group and sputum examination heterogeneous group, with nickel> 2.2μg / g; sputum Check the heterogeneous group