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目的探讨血小板数量和D-二聚体(D-D)含量在弥漫性血管内凝血(DIC)发生过程中的变化。方法胶体金法检测DIC患者及正常对照组血浆中D-D的含量,同时采集全血检测血小板数量。并对12例重型DIC患者血浆中D-D和全血血小板数量进行了为期10 d的动态监测。结果血浆中D-D的含量在DIC组显著增高,与对照组比较差异均有统计学意义(P<0.01)。血小板呈短暂上升后明显降低或与发病初期相比明显降低(P<0.01)。动态观测中,D-D变化不大,而血小板计数短暂上升后明显降低,且随着治疗过程有一定的回升。结论二者联检可以明显提高DIC的诊断效率,且血小板因出现较早且随着治疗的过程能同步变化,可作为一较理想的动态监测指标。
Objective To investigate the changes of platelet count and D-dimer in diffuse intravascular coagulation (DIC). Methods Colloid gold assay DIC patients and normal control group plasma D-D content, while collecting whole blood to detect platelet count. The plasma D-D and whole blood platelet counts in 12 patients with severe DIC were monitored dynamically for 10 days. Results The content of D-D in plasma was significantly higher in DIC group than in control group (P <0.01). Platelets were significantly increased after a brief increase or significantly reduced compared with the early onset (P <0.01). Dynamic observation, D-D little change, and a significant increase in platelet count decreased significantly, and with the course of treatment has a certain rebound. Conclusion The combination of the two can significantly improve the diagnostic efficiency of DIC, and platelets appear earlier and with the course of treatment can be synchronized changes, can be used as an ideal dynamic monitoring indicators.