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本文采用微管吸吮技术研究了脑动脉粥样硬化患者与正常健康人红细胞在吸进微管的变形过程,采用二维Kelivin模型拟合实验结果,定量地比较患者与正常人红细胞膜的粘弹性,并采用新定义的对数还原复粘度法运用Lowshear30等仪器对患者与正常人宏观血液流变学参量之间相关性进行了研究,结果表明:脑动脉粥样硬化患者红细胞弹性系数((5.74±1.77)×10-3dyn/cm)略高于正常人((5.36±056)×10-3dyn/cm),而粘性系数((4.11±1.68)×10-4dyn·s/cm)明显高于正常((1.91±0.96)×10-4dyn·s/cm),全血粘度及对数还原粘弹性L1及L2在由低到高各剪切率下,患者明显高于正常人。红细胞粘滞性增大,变形能力降低,这正是宏观血液流变学指标增高主要原因之一,也可能是造成患者脑硬塞的主要原因。
In this study, microtubule sucking was used to study the process of erythrocytes sucking in microtubules in patients with cerebral atherosclerosis and normal controls. The two-dimensional Kelivin model was used to fit the experimental results to quantitatively compare the viscoelasticity of erythrocyte membrane , And the new definition of log reduction complex viscosity method using Lowshear30 and other instruments on the macroscopic hemorheological parameters of patients and normal correlation was studied, the results showed that: atherosclerosis in patients with erythrocyte elasticity coefficient ((5 .74 ± 1.77 × 10-3dyn / cm) was slightly higher than that of normal people (5.36 ± 056 × 10-3dyn / cm), while the coefficient of viscosity was (4.11 ± 1.68) × 10 -4dyn · s / cm) was significantly higher than normal (1.91 ± 0.96 × 10-4dyn · s / cm), whole blood viscosity and logarithmic reduction viscoelasticity L1 and L2 in the low to high shear Cut rate, the patient was significantly higher than normal. Erythrocyte viscosity increased, reduced ability to deform, which is one of the main macrovascular hematological indicators of increased, may also be the main cause of patients with cerebral edema.