论文部分内容阅读
胃神经内分泌癌(NEC)是一种高度恶性肿瘤。然而,因其罕见,有关其临床病理学特征的资料较少。为此作者分析了51例胃NEC的形态学、免疫组织化学特点及其预后。组织学上,40例为大细胞型,11例为小细胞型。大多数肿瘤为实型生长(94%),部分肿瘤为小梁型(16%)、硬化型(10%)和小管型(6%)。36例(71%)肿瘤伴有腺癌成分和/或间变,其中26例(51%)伴有黏膜内腺癌或间变。免疫组化显示,48例(94%)、44例(86%)和24例(47%)肿瘤分别弥漫性表达突触素、嗜铬粒蛋白A和CD56。两种新近报道的,()()
Gastric neuroendocrine carcinoma (NEC) is a highly malignant tumor. However, because of its infrequency, there is less information on its clinical pathological features. To this end the authors analyzed the morphology of 51 cases of gastric NEC, immunohistochemical features and prognosis. Histologically, 40 cases of large cell type, 11 cases of small cell type. Most of the tumors were real growth (94%), some of the tumors were trabecular (16%), sclerosing (10%) and tubule (6%). Thirty-six patients (71%) had adenocarcinoma and / or metachronous changes, of which 26 (51%) had adenocarcinoma or anaplastic lesions. Immunohistochemistry revealed diffuse expression of synaptophysin, chromogranin A and CD56 in 48 (94%), 44 (86%) and 24 (47%) tumors, respectively. Two newly reported, () ()