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荻田善一等应用遗传工程技术培育了证模型小鼠,对八味地黄丸的作用进行遣传药理学研究,对小鼠颌下腺多激素调节系统进行分子生物学分析,提出了在颌下腺控制生理活性蛋白质基因转录过程有关的多激素调节机制的假说。
Shinoda et al. used genetic engineering techniques to develop rat model mice and conducted pharmacological studies on the effects of Bawei Dihuang Wan. The molecular biological analysis of the submandibular gland multihormone regulatory system was proposed, and the control of physiological activity in the submandibular gland was proposed. The Hypothesis of the Mechanism of Multihormone Regulation Related to Protein Gene Transcription Processes