【摘 要】
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Ischemic stroke contributes up to 80％ of total stroke incidence and is one of the leading causes of death and disability worldwide[1,2].Noteworthily,the inflamma
【机 构】
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Department of Physiology, Faculty of Medicine,University of Toronto, 1 King’s College Circle,Toronto
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Ischemic stroke contributes up to 80％ of total stroke incidence and is one of the leading causes of death and disability worldwide[1,2].Noteworthily,the inflammatory responses triggered after ischemic stroke often amplify and exacerbate the ischemic lesion[2].Insufficient blood supply to brain cells initiates the pathophysiology of ischemic stroke and results in a densely ischemic core surrounded by a poorly perfused region termed ischemic penumbra.Cells within the ischemic area become deprived of oxygen,glucose,and other nutrients.Since oxygen and glucose are critical fuels for brain cell survival,lack of these factors leads to dysfunction of neurons,glial cells,endothelial cells,and pericytes.
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