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目的 :评价血小板聚集 (PA)试验在脑梗塞诊断和防治中的价值。方法 :以二磷酸腺苷 (ADP)、胶原 (Col)及肾上腺素 (Adr)为诱导剂 ,应用多频道血小板聚集仪 ,对 68例急性期或非急性期 (亚急性期或慢性期 )脑梗塞患者及 30例正常对照进行PA检测。结果 :在脑梗塞未用药组 ,急性期患者以ADP和Col为诱导剂 ,PA率均明显低于正常对照组(P <0 0 1 ,P <0 0 5)。而以Adr为诱导剂 ,PA率均明显高于对照组 (P <0 0 5) ;非急性期患者未用药组 ,以ADP、Col及Adr为诱导剂 ,PA率均明显高于对照组 (P <0 0 1 ,P <0 0 5)。在用药组 ,无论急性期或非急性期患者 ,3种诱导剂的PA率均明显低于对照组 (P<0 0 1 )。结论 :以ADP、Col及Adr为诱导剂 ,在脑梗塞不同期进行PA检测 ,对脑梗塞的诊断及指导治疗均有一定的价值。PA检测可作为脑梗塞治疗结果的监测。
Objective: To evaluate the value of platelet aggregation (PA) test in the diagnosis and prevention of cerebral infarction. Methods: A total of 68 acute or non-acute (subacute or chronic) brain regions were treated with adenosine diphosphate (ADP), collagen (Col) and adrenaline Patients with infarction and 30 normal control PA test. Results: In the non-medication group of cerebral infarction, the acute rejection rate of ADP and Col were significantly lower than those of normal control group (P <0.01, P <0.05). However, with Adr as the inducer, the PA rate was significantly higher than that of the control group (P <0 05). In the non-acute phase, the PA rate was significantly higher in the non-acute patients than in the control group with ADP, Col and Adr as the inducer P <0 0 1, P <0 0 5). In the medication group, the PA rates of three kinds of inducers were significantly lower than those of the control group (P <0.01) in both acute and non-acute patients. Conclusion: Using ADP, Col and Adr as inducing agents to detect PA during different stages of cerebral infarction, it is of value to the diagnosis and treatment of cerebral infarction. PA test can be used as a result of the monitoring of cerebral infarction.